In the last years, metabolomics has contributed greatly to the understanding of cancer biology. In analogy to genomics and proteomics, the term metabolomics can be defined as the study of the complete ensemble of all small molecules (molecular weight (MW) < 1500 Da), including lipids, oligopeptides, nucleotides, amino acids, sugars, and metabolic intermediates, formed by numerous biosynthetic and catabolic pathways within a biological system or originating from host-specific microbes and the intake of food nutrients and pharmaceuticals, which are present in a cell, tissue, or biofluids such as urine, blood or saliva, in the context of a physiological or pathological condition.
TECHNIQUES UTILIZED IN THE ASSESSMENT OF METABOLITES
Metabolomics has developed with an exponential speed over the last years as confirmed by the increasing number of scientific publications. The innovation is driven by the development of more sensitive and robust analytical instrumentation and new methods of data analysis. Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS) are recognized as the most powerful techniques used for the high-throughput investigation of the metabolome, with specific advantages and limitations.
Although MS-based approaches are the most sensitive of all techniques, the drawback of MS is the lower reproducibility than NMR spectroscopy. NMR-based metabolomics is a particularly powerful approach when applied to the high-throughput analysis of biofluids such as blood and urine. NMR spectroscopy has been confirmed to be a straightforward and useful technique for the qualitative and quantitative analysis of a wide range of components, including low-molecular-weight metabolites, lipids, and lipoproteins (different for size and composition).
WHAT DO WE OFFER?
We offer scalable, customizable research services to academic and commercial investigators in every area of the life sciences. Our technology is based on the state-of-the-art of NMR spectroscopy techniques. Our proprietary software allows the detection and quantification of metabolites in the NMR spectra. This quantitative information gives you a clearer understanding of your experiments and rapid translation into clinical settings. We use our technology to advance precision medicine and develop novel metabolomics-based clinical diagnostic tests that may improve early detection of diseases. Our technology is designed to overcome the limitations of current clinical diagnostics and enables focus on improving individual health.